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Abstract #4383

Intravoxel Incoherent Motion Diffusion Weighted Imaging of Prostate Cancer

Lei Qin1, Daniel I Glazer2, Pelin Aksit Ciris2, Andriy Fedorov2, Thiele Kobus3, Fiona M Fennessy1,2, Stephan E Maier2, and Robert Mulkern4

1Dana-Farber Cancer Institute, Brookline, MA, United States, 2Brigham and Women's Hospital, Boston, MA, United States, 3Raboud university medical center, Nijmegen, Netherlands, 4Boston Children's Hospital, Boston, MA, United States

Intravoxel Incoherent Motion (IVIM) DWI was acquired with 13 b-values, ranging from 0 to 250 s/mm2. With such low b-values, a short TE results in a better signal-to-noise ratio. Monoexponential fitting was performed to obtain ADC, and biexponential fitting was performed to obtain diffusion D, perfusion fraction f, and perfusion related pseudo-diffusion coefficient D*. In a prostate cancer (PCa) patient cohort, we only found a significant difference between normal and tumor tissue for D, which was absent in ADC, f, and D*. This suggests that IVIM biexponential analysis can help remove perfusion component from diffusion, leading to a more accurate measurement in diffusion coefficient.

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