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Abstract #4451

Breast Lesion Detection and Characterization with Contrast-Enhanced Magnetic Resonance Imaging: Prospective Randomized Intra-individual Comparison of Gadoterate Meglumine versus Gadobenate Dimeglumine at 3 Tesla

Paola Clauser1, Thomas H. Helbich1, Panagiotis Kapetas1, Maria Bernathova1, Katja Pinker1, and Pascal A.T. Baltzer1

1Medical University of Vienna, Vienna, Austria

The aim of our study was to compare a 0.075 mmol/kg dose of gadobenate dimeglumine, with a 0.15 mmol/kg dose of gadoterate meglumine for breast lesion detection and characterization at 3T-MRI. Patients included underwent two examinations, 24-72h apart, one with gadobenate and one with gadoterate administered in randomized order. Three readers evaluated the examinations and diagnostic performance was calculated and compared. 104 women with 142 histologically verified breast lesions (109 malignant, 33 benign) were included. Detection with gadobenate was comparable to gadoterate (p>0.165). Gadobenate demonstrated significantly higher specificity and accuracy (p<0.007). Multivariate analysis demonstrated reader-independent superior diagnostic accuracy with gadobenate.

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