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Abstract #4481

Using Regional Gas-Phase Saturation to Localize Hyperpolarized Xenon-129 Spectroscopy Measurements

Kai Ruppert1, Hooman Hamedani1, Faraz Amzajerdian1, Luis Loza1, Yi Xin1, Ian F. Duncan1, Harilla Profka1, Sarmad Siddiqui1, Mehrdad Pourfathi1, Stephen Kadlecek1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Chemical Shift Saturation Recovery MR spectroscopy is becoming a powerful tool for quantifying alveolar gas exchange, but is currently predominantly used for whole-lung assessments. In this study, we investigated the feasibility of regional gas-phase saturation as a tool for coarse spatial localization, testing its utility in a rat model of radiation-induced lung injury. We found a large decrease in the ratio between the red-blood-cell and tissue / plasma peaks in the irradiated lung relative to the lungs in a healthy animal. Our approach might be particularly useful for assessing highly heterogeneous disease patterns (radiation-induced lung injuries, lung transplants, etc.).

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