Abstract #4488

Amide proton transfer-weighted (APTW) MRI as an in vivo molecular imaging biomarker to detect prostate cancer

Xiaoxi Chen¹, Lianming Wu¹, Weibo Chen², Jinyuan Zhou³, and Jianrong Xu¹

¹Department of Radiology, Renji Hospital, Shanghai, China, ²Philips Healthcare, Shanghai, China, ³Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

We explored the capability of using the amide proton transfer-weighted MR imaging as a molecular imaging biomarker to identify prostate cancer. Results showed that both the amide proton transfer ratio (APTR) and magnetization transfer ratio (MTR) in tumors were higher than in non-tumorous regions. APT-MR imaging may have great value in clinical treatment and prognosis of prostate cancer.

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