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Abstract #4488

Amide proton transfer-weighted (APTW) MRI as an in vivo molecular imaging biomarker to detect prostate cancer

Xiaoxi Chen1, Lianming Wu1, Weibo Chen2, Jinyuan Zhou3, and Jianrong Xu1

1Department of Radiology, Renji Hospital, Shanghai, China, 2Philips Healthcare, Shanghai, China, 3Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

We explored the capability of using the amide proton transfer-weighted MR imaging as a molecular imaging biomarker to identify prostate cancer. Results showed that both the amide proton transfer ratio (APTR) and magnetization transfer ratio (MTR) in tumors were higher than in non-tumorous regions. APT-MR imaging may have great value in clinical treatment and prognosis of prostate cancer.

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