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Abstract #4490

Intra- and Inter-scanner Variability Evaluation of RR-VFA B1+ and T1 in the Prostate at 3T

Xinran Zhong1,2, Dapeng Liu1, James Sayre1, Holden H Wu1,2, and Kyunghyun Sung1,2

1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States

Accurate T1 estimation is critical for quantitative prostate DCE MRI. B1+ inhomogeneity can introduce significant error into the T1 quantification, especially for variable flip angle method. Reference region variable flip angle (RR-VFA) method is a promising B1+ and T1 estimation technique, which requires no separate scans for B1+ mapping and can reduce slice profile and position mismatch between B1+ and T1 maps. In this study, we investigated both intra-scanner repeatability and inter-scanner reproducibility regarding B1+ corrected T1 on two 3.0 T scanners to compare RR-VFA to a commercially available B1+ estimation technique. RR-VFA showed comparable intra- and inter-scanner variability to the saturated turbo FLASH based B1+ estimation technique.

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