Abstract #4496

Two compartment fitting for Luminal Water Imaging: multi-echo T2 in Prostate Cancer

William Devine¹, Francesco Giganti², Edward Johnston¹, Eleftheria Panagiotaki³, Shonit Punwani¹, Daniel C. Alexander³, and David Atkinson¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Department of Radiology, University College London Hospital NHS Foundation Trust, London, United Kingdom, ³Centre for Medical Image Computing, University College London, London, United Kingdom

This work aims both to show that using a constrained fitting method for Luminal Water Imaging with fewer echoes produces accurate parameter estimates and that this fitting method is feasible for detecting and grading Prostate Cancer. Simulated signals were produced and the mean LWF across multiple iterations was calculated for two models. Then 19 patients were imaged and the images were contoured in both cancerous and benign regions. The simulation showed that the proposed constrained method is accurate and the in-vivo imaging reinforced the idea that multi-echo T2 modelling shows promise in detecting and grading PCa.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.