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Abstract #4496

Two compartment fitting for Luminal Water Imaging: multi-echo T2 in Prostate Cancer

William Devine1, Francesco Giganti2, Edward Johnston1, Eleftheria Panagiotaki3, Shonit Punwani1, Daniel C. Alexander3, and David Atkinson1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Department of Radiology, University College London Hospital NHS Foundation Trust, London, United Kingdom, 3Centre for Medical Image Computing, University College London, London, United Kingdom

This work aims both to show that using a constrained fitting method for Luminal Water Imaging with fewer echoes produces accurate parameter estimates and that this fitting method is feasible for detecting and grading Prostate Cancer. Simulated signals were produced and the mean LWF across multiple iterations was calculated for two models. Then 19 patients were imaged and the images were contoured in both cancerous and benign regions. The simulation showed that the proposed constrained method is accurate and the in-vivo imaging reinforced the idea that multi-echo T2 modelling shows promise in detecting and grading PCa.

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