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Abstract #4516

Estimation of simultaneous BOLD and FDG metabolism activation using a coherent ICA method

Shenpeng Li1,2, Francesco Sforazzini2, Sharna D. Jamadar2,3,4, Philllip G.D. Ward2,3,4, Jakub Baran2, Malin Premaratne1, Gary Egan2,3,4, and Zhaolin Chen1,2

1Department of Electrical and Computer System Engineering, Monash University, Clayton, Australia, 2Monash Biomedical Imaging, Monash University, Clayton, Australia, 3Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University, Clayton, Australia, 4Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Clayton, Australia

This abstract proposes a new joint fMRI and functional FDG-PET (fPET) ICA analysis method, coherent ICA, based on the simultaneously acquired dual-modality imaging data. It applies ICA on the spatiotemporal data sets from both modalities to obtain coherent activation maps and preserve their correspondent temporal information, which is not retained by existing methods. The preserved temporal information can potentially be used to investigate the interaction between BOLD signal and other metabolism change measured by fPET.

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