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Abstract #4518

Level of TMS-evoked activation in anterior cingulate cortex depends on timing of TMS delivery relative to frontal alpha phase

Golbarg T. Saber1, James R. McIntosh2, Jayce Doose1, Josef Faller2, Yida Lin2, Hunter Moss1, Robin I. Goldman3, Mark S. George4,5, Paul Sajda2, and Truman R. Brown1

1Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, 2Department of Biomedical Engineering, Columbia University, New York, NY, United States, 3Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, United States, 4Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, 5Ralph H. Johnson VA Medical Center, Charleston, SC, United States

To test whether the level of activation of the anterior cingulate cortex (ACC) following a TMS pulse delivered to the dorsolateral prefrontal cortex depends on precise timing of its delivery relative to an individual’s alpha rhythm, we developed an integrated EEG-fMRI-TMS instrument capable of acquiring simultaneous EEG-fMRI while delivering TMS pulses in the scanner. We found a statistically significant effect of BOLD signal change in ACC dependent on individual subject frontal alpha phase just prior to TMS delivery. Specifically, TMS-evoked BOLD response in the ACC increased when TMS pulse was synchronized to the rising slope of the frontal alpha oscillation.

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