Abstract #4518

Level of TMS-evoked activation in anterior cingulate cortex depends on timing of TMS delivery relative to frontal alpha phase

Golbarg T. Saber¹, James R. McIntosh², Jayce Doose¹, Josef Faller², Yida Lin², Hunter Moss¹, Robin I. Goldman³, Mark S. George^4,5, Paul Sajda², and Truman R. Brown¹

¹Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, ²Department of Biomedical Engineering, Columbia University, New York, NY, United States, ³Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States, ⁵Ralph H. Johnson VA Medical Center, Charleston, SC, United States

To test whether the level of activation of the anterior cingulate cortex (ACC) following a TMS pulse delivered to the dorsolateral prefrontal cortex depends on precise timing of its delivery relative to an individual’s alpha rhythm, we developed an integrated EEG-fMRI-TMS instrument capable of acquiring simultaneous EEG-fMRI while delivering TMS pulses in the scanner. We found a statistically significant effect of BOLD signal change in ACC dependent on individual subject frontal alpha phase just prior to TMS delivery. Specifically, TMS-evoked BOLD response in the ACC increased when TMS pulse was synchronized to the rising slope of the frontal alpha oscillation.

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