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Abstract #4528

BOLD-MRI imaging for the evaluation of hepatic warm ischemia-reperfusion injury and the effect of Lipo-PGE1 intervention in rabbit models

Qian Ji1, Jingyao Li2, Tianyi Qian3, and Jinxia Zhu3

1Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 2First Central Clinical College of Tianjin Medical University, Tianjin, China, 3Siemens Healthcare, Beijing, China

This study aimed to determine the feasibility of using BOLD MRI to diagnose liver ischemia-reperfusion injury and the effect of Lipo-PGE1 intervention in rabbits. Seven groups of rabbits with liver ischemia-reperfusion injury induced using various means were examined using a 3T clinical MR scanner and followed by biochemical and histopathological analysis. The R2* values were significantly positively correlated with alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase. These results suggest that BOLD MRI is suitable for quantitatively assessing the degree of ischemia and the effect of Lipo-PGE1 in rabbits.

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