Wilms Tumour (WT) is a paediatric renal tumour. Identifying necrosis in WT is clinically important; it can assess patients’ chemotherapy response and ultimately predict progression-free survival. It is also important for guiding biopsies. Lack of enhancement following intravenous administration of gadolinium is commonly used to identify necrosis, however, WT is a kidney tumour, and the use of gadolinium is contra-indicated in patients with renal failure. In this study we demonstrate how apparent diffusion coefficient values from DWI and pre-gad T1 imaging can predict the level of enhancement in WT, and quantify the percentage of necrotic tissue without exogenous contrast agents.
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