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Abstract #4585

ADC and T1-weighted MRI Identifies Necrosis in Wilms Tumours Without the Need for Contrast Agents

Harriet Rogers1, Martijn Verhagen 2, Christopher Clark1, and Patrick Hales1

1Great Ormond Street Institute of Child Health, University College London, London, United Kingdom, 2Great Ormond Street Hospital, London, United Kingdom

Wilms Tumour (WT) is a paediatric renal tumour. Identifying necrosis in WT is clinically important; it can assess patients’ chemotherapy response and ultimately predict progression-free survival. It is also important for guiding biopsies. Lack of enhancement following intravenous administration of gadolinium is commonly used to identify necrosis, however, WT is a kidney tumour, and the use of gadolinium is contra-indicated in patients with renal failure. In this study we demonstrate how apparent diffusion coefficient values from DWI and pre-gad T1 imaging can predict the level of enhancement in WT, and quantify the percentage of necrotic tissue without exogenous contrast agents.

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