Abstract #4587

MR elastography and US elastography for assessment of renal transplant dysfunction: preliminary results.

Paul Kennedy^1,2, Octavia Bane^1,2, Sonja Gordic^2,3, Stefanie Hectors^1,2, Mark Berger^1,2, Rafael Khaim⁴, Veronica Delaney⁴, Madhav Menon⁴, Fadi El Salem⁵, Sara Lewis^1,2, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ²Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ³University Hospital Zurich, Zurich, Switzerland, ⁴Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States, ⁵Pathology, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States

The aim of this study is to determine whether MR and US elastography methods can differentiate functional and chronically dysfunctional renal allografts by measuring renal corticomedullary stiffness with MR elastography (MRE) and cortex stiffness with ultrasound point shear wave elastography (pSWE). Our preliminary results indicate that renal stiffness measured with MRE is significantly increased in dysfunctional kidneys, while no significant difference was found with pSWE. Renal stiffness measured with MRE also significantly correlated with Banff scores for interstitial fibrosis and tubular atrophy. These preliminary results suggest that MRE is sensitive to fibrotic changes in chronically dysfunctional allografts.

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