Abstract #4615

Late gadolinium MRI hyperintensity of colorectal liver metastases with extracellular contrast agents (gadobutrol) versus intravascular contrast agents (gadofosveset)

Helen Cheung¹, Natalie Coburn², Paul J Karanicolas², Calvin Law², John M Hudson¹, and Laurent Milot¹

¹Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ²Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

Late gadolinium hyperintensity (LGH) of colorectal liver metastases (CRCLM) using MRI with extracellular contrast agents presents a diagnostic dilemma that is commonly encountered clinically because it can be difficult to distinguish from benign hemangiomas. CRCLM may demonstrate less LGH using MRI with intravascular contrast agents due to reduced retention of contrast within these lesions. Approximately half of CRCLM demonstrate LGH on MRI with extracellular contrast agents versus only 6% on MRI with intravascular contrast agents. LGH is significantly better at excluding malignancy in patients with intravascular agents compared with extracellular contrast agents and may be a clinically useful problem-solving tool.

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