Meeting Banner
Abstract #4622

Toward quantification of renal tubular volume fraction using diffusion-weighted split-echo RARE in conjunction with a three-compartment IVIM model

Joao Periquito1, Katharina Paul1, Till Huelnhagen1, Yiyi Ji1, Min-Chi Ku1, Sarah Brix2, Kathleen Cantow2, Erdmann Seeliger2, Bert Flemming2, Thomas Gladytz3, Dirk Grosenick3, Andreas Pohlmann1, and Thoralf Niendorf1,4

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute for Vegetative Physiology, Charité – University Medicine Berlin, Berlin, Germany, 3Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

T2* mapping does not fully represent renal tissue oxygenation. Diffusion-weighted imaging (DWI) can provide information about confounding factors such as tubular volume fraction, which can be used to correct T2*. By using a three compartment IVIM model, tubular volume fraction can be mapped with DWI. The most widely used DWI technique is spin-echo EPI which is sensitive to magnetic field inhomogeneities and hence prone to geometric distortions. In this work we propose a diffusion-weighted Rapid Acquisition Relaxation Enhancement (RARE) variant for DWI of the rat kidney free of geometric distortions to quantify tubular volume fraction at 9.4 Tesla.

This abstract and the presentation materials are available to members only; a login is required.

Join Here