Abstract #4622

Toward quantification of renal tubular volume fraction using diffusion-weighted split-echo RARE in conjunction with a three-compartment IVIM model

Joao Periquito¹, Katharina Paul¹, Till Huelnhagen¹, Yiyi Ji¹, Min-Chi Ku¹, Sarah Brix², Kathleen Cantow², Erdmann Seeliger², Bert Flemming², Thomas Gladytz³, Dirk Grosenick³, Andreas Pohlmann¹, and Thoralf Niendorf^1,4

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine, Berlin, Germany, ²Institute for Vegetative Physiology, Charité – University Medicine Berlin, Berlin, Germany, ³Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ⁴Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

T₂* mapping does not fully represent renal tissue oxygenation. Diffusion-weighted imaging (DWI) can provide information about confounding factors such as tubular volume fraction, which can be used to correct T₂*. By using a three compartment IVIM model, tubular volume fraction can be mapped with DWI. The most widely used DWI technique is spin-echo EPI which is sensitive to magnetic field inhomogeneities and hence prone to geometric distortions. In this work we propose a diffusion-weighted Rapid Acquisition Relaxation Enhancement (RARE) variant for DWI of the rat kidney free of geometric distortions to quantify tubular volume fraction at 9.4 Tesla.

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