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Abstract #4626

Prediction of treatment response based on baseline volumetric functional MR imaging criteria in patients with unresectable HCC who are candidate for Trans-Arterial Chemoembolization.

Mounes Aliyari Ghasabeh1, Ankur Pandey2, Sanaz Ameli2, Pallavi Pandey2, pegah Khoshpouri3, Yan luo3, Farnaz Najmi varzaneh4, Manijeh Zargham pour3, and Ihab R. Kamel3

1John Hopkins Hospital, Baltimore, MD, United States, 2Johns Hopkins Hospital, Baltimore, MD, United States, 3Johns Hopkins Hospital, baltimore, MD, United States, 4johns Hopkins Hospital, Baltimore, MD, United States

Synopsis: Predicting overall survival in HCC patients before initiating treatment is essential to personalize a treatment plan for each patient. Barcelona clinic liver cancer (BCLC) is one of the current criteria for predicting pre-therapeutic overall survival (OS). Several studies suggested a valuable role of functional MRI biomarkers including diffusion-weighted imaging (DWI) with apparent diffusion coefficients (ADC), tumor venous enhancement (VE) and tumor volume (TV) in tumor response assessment. These metrics rely on changes post therapy; none of these parameters assessed baseline values of these variables in predicting OS before starting treatment.

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