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Abstract #4634

Brain or cardiovascular oscillation: ultra-slow oscillations under 0.01 Hz detected by resting-state fMRI

Patricia Pais Roldán1,2, Brian Edlow3, Johannes Stelzer1, Yuanyuan Jiang1, and Xin Yu1

1Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Graduate Training Centre of Neuroscience, Tübingen, Germany, 3Massachusetts General Hospital, Boston, MA, United States

A high amplitude slow wave component of frequency 0.005 to 0.012 Hz was observed in multiple resting state fMRI scans of the rat brain under different anesthetics. These ultra-slow waves were localized predominantly in the hypothalamus. We hypothesize that these ultra-slow oscillations might have a neurological origin and may contribute to the analysis of resting state connectivity, which is currently limited to frequencies above 0.01 Hz . Future studies should investigate the origin of these oscillations with an independent measure (e.g. calcium imaging) and the implications of their incorporation into the analysis of rs-fMRI.

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