Abstract #4639

Demonstration of brain tumor-induced neurovascular uncoupling within the language network at ultra-high field

Shruti Agarwal¹, Jun Hua^2,3, Haris I. Sair¹, Hanzhang Lu^2,3, and Jay J. Pillai^1,4

¹Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center For Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

False-negative activations caused by neurovascular uncoupling (NVU) can lead to erroneous interpretation of clinical BOLD fMRI examinations. At 7T, spatial specificity can be improved relative to clinical 3T imaging. In this study, we demonstrate that NVU within the language network may affect the resting-state (rsfMRI) frequency domain metric ALFF (amplitude of low-frequency fluctuation) and breathhold cerebrovascular reactivity (BH CVR) maps as evident in the criterion standard task fMRI at ultra-high field despite known substantial BOLD signal-to-noise ratio advantages provided by higher field strength, which may not fully mitigate the effects of such NVU.

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