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Abstract #4649

Vascular Origins of “Anti-correlations” in Resting-State fMRI

Mahdi Khajehim1 and J. Jean Chen1,2

1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute, Baycrest, Toronto, ON, Canada

Several explanations for the existence of anti-correlations in rsfMRI have been suggested so far, ranging from true neural activity to a side effect of preprocessing. In this abstract, we investigate the possible vascular origins of anti-correlation by presenting a biophysical model that is inspired by past simulation studies. Our model suggests resting-state BOLD anti-correlations across voxels may arise simply from the physiological and magnetic properties of arterial and venous blood, and may not be solely due to anti-correlated neural activity.

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