Local aggressiveness of endometrial cancer (EC) including the quantification of myometrial invasion, the exclusion of cervical stromal infiltration, lymphovascular space invasion (LVSI), etc, are closely related to EC risk classification, development, prognosis and surgical procedures. The ADC and IVIM-derived parameters can quantitatively assess tumor microstructure which is correlated to tumor development and aggressiveness. Our results showed that ADC and some of IVIM parameters demonstrated good diagnostic performance in the identification of deep myometrial invasion, cervical stromal infiltration and LVSI. IVIM DWI could provide valuable information about local aggressiveness of EC preoperatively which contribute to clinical decision-making and prognosis prediction.
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