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Abstract #4687

Diffusion kurtosis imaging for the diagnosis and prediction of response to treatment in high grade serous ovarian cancer

Surrin Deen1, Andrew N Priest2, Mary A McLean3, Andrew B Gill2, Helena Earl2, Christine Parkinson2, Sarah Smith2, Robin Crawford2, John Latimer2, Peter Baldwin2, Helen Addley2, Susan Freeman2, Charlotte Hodgkin2, Ilse Patterson2, Mercedes Jimenez-Linan 2, James Brenton2,3, and Ferdia Gallagher1,2

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Addenbrooke's Hospital, Cambridge, United Kingdom, 3Cancer Research UK, Cambridge, United Kingdom

Diagnosis of high grade serous ovarian cancer (HGSOC) requires a biopsy which is both invasive and does not reflect the heterogeneity of the disease. Diffusion kurtosis imaging (DKI) was performed on 23 treatment naïve ovarian cancer patients. Both mean Dapp (apparent diffusion) and mean Kapp (apparent kurtosis) were found to be significantly different in HGSOC compared to other types of epithelial cancer. Kapp was also significantly greater in the patients who went on to respond to chemotherapy treatment compared to non-responders. DKI may therefore aid in identifying HGSOC and in the selection of the best treatment for individual patients.

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