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Abstract #4693

Characterization of uterine artery geometry in normal pregnancy with time-of-flight angiography

Eileen Hwuang1, M. Dylan Tisdall1, Nadav Schwartz1, John A. Detre1, and Walter R. Witschey1

1University of Pennsylvania, Philadelphia, PA, United States

While measuring uterine artery (UtA) impedance is commonly used to assess for risk of preeclampsia and intrauterine growth restriction, little is understood about the remodeling process during gestation. An improved understanding of geometrical changes can lead to predictive biomarkers of adverse pregnancies. Here we present a method of measuring path length and curvature of the tortuous UtAs by segmentation and centerline extraction of time-of-flight MR angiography. We show in 8 pregnant subjects in the 2nd and 3rd trimester that this technique is feasible for investigating longitudinal trends of UtA remodeling and cases of maladaptation.

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