Abstract #4695

Placental perfusion imaging using velocity-selective arterial spin labeling

Zungho Zun^1,2,3,4 and Catherine Limperopoulos^1,2,3,4

¹Division of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC, United States, ²Division of Fetal and Transitional Medicine, Children’s National Medical Center, Washington, DC, United States, ³Department of Pediatrics, George Washington University, Washington, DC, United States, ⁴Department of Radiology, George Washington University, Washington, DC, United States

Recently placental perfusion imaging using velocity-selective arterial spin labeling (VSASL) was applied in pregnancies complicated by fetal heart disease. Here we demonstrate the feasibility of performing VSASL in the human placenta and provide supporting evidence that is needed for validation of placental VSASL. In our results, placental VSASL generated significantly higher ASL signal than pseudocontinuous ASL, showed high reproducibility, and demonstrated inflow-dependence. This study lays the groundwork for future investigation of placental perfusion imaging in pregnancies complicated by placental insufficiency.

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