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Abstract #4699

Placental Insufficiency Investigated with Multi-compartment Placental MRI

Andrew Melbourne1, Rosalind Aughwane1, David Owen1, Magdalena Sokolska2, Alan Bainbridge2, David Atkinson1, Jan Deprest1, Giles Kendall2, Tom Vercauteren1, Anna David2, and Sebastien Ourselin1

1University College London, London, United Kingdom, 2University College Hospital, London, United Kingdom

Efficient exchange of oxygen and nutrients across the placenta is vital for a normally grown fetus. When remodelling of maternal arteries does not occur in early pregnancy the result is placental insufficiency, and fetal growth restriction. Previous studies have shown differences in T2 relaxometry and IVIM between normal and FGR placentae. Here we use a combined T2R and IVIM signal model that separates signals from fetal and maternal blood pools over the whole placental volume. We show difference in T2R, ADC, and maternal perfusion fraction, findings in keeping with previous literature and the pathophysiology of placental insufficiency.

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