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Abstract #4702

Imaging beta-cell function in the mouse pancreas with an implanted imaging window by MRI

Veronica Clavijo Jordan1, Xiaodong Wen1, Filip Bochner2, Su-Tang Lo1, Andre F. Martins1,3, Sara Chirayil1, Michal Neeman2, and A. Dean Sherry1,3

1University of Texas Southwestern Medical Center, Dallas, TX, United States, 2The Weizmann Institute of Science, Rehovot, Israel, 3University of Texas at Dallas, Richardson, TX, United States

We have successfully implanted an imaging window onto the mouse abdomen to locate and hold the tail of the pancreas in place. By use of this MR-compatible window we were able to show with MRI and a Gd-based zinc sensor the non-uniform regional secretion of zinc and insulin as a response to glucose in the tail of the mouse pancreas. This surgical technique and imaging technology could be used to successfully monitor beta-cell function longitudinally through the development of the various diseases of the endocrine pancreas with MRI.

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