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Abstract #4704

Treatment effect of autoimmune pancreatitis: evaluation with T1 mapping

Liang Zhu1, Hua-dan Xue1, Zhao-yong Sun1, Marcel Dominik Nickel2, Tianyi Qian3, and Zheng-yu Jin4

1Radiology, Peking Union Medical College Hospital, Beijing, China, 2Siemens Healthcare, Erlangen, Germany, 3Siemens Healthcare, Beijing, China, 4Peking Union Medical College Hospital, B, China

This prospective study aims to evaluate the T1 relaxation time of autoimmune pancreatitis (AIP) in the native state and after corticosteroid treatment (CST). Thirty-four patients with AIP and twenty control subjects received pancreatic MR including T1 mapping. All AIP patients had T1 mapping data before and after CST. It turned out that the inflamed pancreatic parenchyma had significantly elongated T1 relaxation time, and after 4-12 weeks of CST, the T1 relaxation time shortened significantly towards normalization, in keeping with the serum biomarkers of disease activity. Therefore MR T1 mapping is a noninvasive, quantitative method to monitor AIP treatment effect.

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