Abstract #4752

Accelerated Coronary 4D-Flow MRI: towards noninvasive functional assessment of stable coronary artery disease

Zixin Deng¹, Michael Loecher², Anthony Christodoulou¹, Christopher Nguyen¹, Zhengwei Zhou¹, Jaime Shaw¹, Yibin Xie¹, Xiaoming Bi³, Zhaoyang Fan¹, Daniel Ennis², and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare R&D, Los Angeles, CA, United States

In patients with suspected coronary artery disease (CAD), invasive catheterization is commonly used to determine the need for coronary revascularization. However, recent studies have shown that >50% of patients who undergo invasive catheterization have non-significant coronary lesions, hence the procedure was unnecessary. Recent work using 4D-Flow and the Navier-Stokes equations has shown promise for the noninvasive assessment of CAD, but still requires long scan times. This work explored coronary 4D-Flow using a stack-of-stars acquisition and compressed sensing to achieve 2-3x acceleration. The goal was to develop a more clinically feasible noninvasive pressure gradient measurement method for the assessment of CAD.

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