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Abstract #4781

Influence of contrast, sequence, threshold, and observer on 3D segmentation of the right ventricular outflow tract for intervention planning

Barbara Elisabeth Ursula Burkhardt1,2, Nicholas K. Brown2, Jaclyn E. Carberry3, MarĂ­ Nieves Velasco Forte3, Nicholas Byrne3, Tarique Hussain2,3, Gerald Greil2,3, and Animesh Tandon2

1Pediatric Heart Center, Cardiology, University Children's Hospital Zurich, Zurich, Switzerland, 2Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Three-dimensional reconstructions of cardiac magnetic resonance (CMR) datasets vary with contrast, image sequence, segmentation threshold, and manual post-processing. These influences need to be assessed before CMR-based models are used for interventional planning.

Three-dimensional segmentations of the right ventricular outflow tract (RVOT) from twelve patients with three different angiography sequences were compared between and within observers using different or the same thresholds.

Thresholding was sequence-dependent and did not significantly change object volumes. Minimal diameters of 3D reconstructed RVOTs showed clinically significant variation with different thresholds and between observers.

Interventional planning should rely on source images, not three-dimensional reconstructions, for quantitative information.

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