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Abstract #4788

Augmenting the interpretation of cardiac MRI by biomechanical modeling: Application to tetralogy of Fallot

Radomir Chabiniok1,2,3, Reagan M. Tompkins4, Maria Gusseva1, Animesh (Aashoo) Tandon4, Gerald Greil3,4, Philippe Moireau1,2, Dominique Chapelle1,2, and Tarique Hussain3,4

1Inria, Paris-Saclay University, Palaiseau, France, 2LMS, Ecole Polytechnique, Paris-Saclay University, Palaiseau, France, 3School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 4Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States

We propose connecting the acquisition and processing of cardiovascular MR (CMR) data with biomechanical cardiac modeling. Physical and physiological character predisposes biomechanical models to predictivity, and CMR data turn them into patient-specific regime. A high computational demand is addressed by applying a spatially-reduced model: the geometry and kinematics are simplified, but all other physical properties kept. The approach is illustrated by example of Tetralogy of Fallot patients, in whom we are able to access the myocardial contractility pre- and post-pulmonary valve replacement aiming at deciding on optimal therapy timing – the problem that has not been completely solved by sole CMR.

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