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Abstract #4823

Reproducibility of BOLD delay perfusion measurements in acute stroke patients

Ahmed A Khalil1,2,3, Ayse Ceren Tanritanir1, Ulrike Grittner1,4, Arno Villringer2,3, Jochen Fiebach1, and Ralf Mekle1

1Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Berlin School of Mind & Brain, Humboldt Universität zu Berlin, Berlin, Germany, 3Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Department of Biostatistics and Clinical Epidemiology, Charité Universitätsmedizin Berlin, Berlin, Germany

To assess perfusion in ischemic stroke is an important task in clinical diagnosis. In this context, a technique sensitive to the delay of blood-oxygenation-level-dependent (BOLD) oscillations at rest called BOLD delay has been proposed. In this study, the reproducibility of this technique in acute stroke patients was examined. Magnitude differences between perfusion measurements from two timepoints were calculated and evaluated in a statistical model. In particular, the effect of head motion was considered. Reproducibility was found to be limited by motion, but the magnitude of the observed variations was small compared to delays observed due to hypoperfusion in stroke patients.

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