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Abstract #4826

Oxygen extraction fraction is elevated in acute stroke with evidence of preserved metabolism: a quantitative susceptibility MRI study

Audrey P. Fan1, Ahmed A. Khalil2, Jochen Fiebach2, Arno Villringer3, Greg Zaharchuk1, Kersten Villringer2, and Claudine J. Gauthier4

1Stanford University, Stanford, CA, United States, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Concordia University, Montreal, QC, Canada

We utilized a novel MRI susceptibility method to quantify oxygen extraction fraction (OEF) in cortical vessels of 22 patients with acute stroke. The observed OEF ratio between affected and contralateral hemispheres depended on patient perfusion status, and tended to normalize (decrease) in follow-up scans on average 3 days later. Stroke cases with substantial perfusion-diffusion mismatch (indicative of potentially salvageable penumbra) showed the greatest OEF elevation (OEF ratio = 1.2 ± 0.1). Patients with large mismatch also showed an inverse relationship between OEF and relative cerebral blood flow (from dynamic susceptibility contrast), suggestive of mechanisms to maintain tissue oxygen metabolism even in ischemic tissue.

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