Abstract #4846

Mutual Information: Depicting the Interdependence of Perfusion and Diffusion Magnetic Resonance Imaging in Glioblastoma Patients

Chao Li^1,2, Shuo Wang³, Turid Torheim⁴, Florian Markowetz⁴, and Stephen J Price¹

¹Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom, ²Department of Neurosurgery, Shanghai General Hospital, Shanghai, China, ³Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ⁴Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom

The mismatch between energy demands of tumor growth and heterogeneous blood supply may cause variations is associated with tumor aggressiveness. Multi-parametric imaging may enable incorporation of complementary imaging modalities. However, finding validated surrogates to depict the interrelation between imaging modalities remains a challenge. We used the mutual information to describe the interrelation between the perfusion and diffusion imaging. The results showed that the higher values of mutual information may contribute to a worse patient survival. The chemical shift imaging results suggested that the higher mutual information may be correlated with a more migratory phenotype.

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