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Abstract #4858

High Resolution T1-Perfusion using Compressed-SENSE for Glioma Grading

Rakesh Kumar Gupta1, Indrajit Saha2, Anup Singh3, Pradeep Kumar Gupta1, Rupsa Bhattacharjee 2, Anandh K Ramaniharan 4, Rana Patir5, Sunita Ahlawat6, Jitender Saini7, and Marc Van Cauteren8

1Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, 2Philips Health Systems, Philips India Limited, Gurgaon, India, 3Center for Biomedical Engineering, Indian Institute of Technology Delhi, Delhi, India, 4Philips Innovation Campus, Philips India Limited, Bangalore, India, 5Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India, 6SRL Diagnostics, Fortis Memorial Research Institute, Gurgaon, India, 7Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, 8Philips HealthTech Asia Pacific, Tokyo, Japan

T1-perfusion MRI derived relative cerebral blood volume (rCBV) is a key bio-marker for pre-surgical grading of gliomas; however, acquiring clinically relevant higher resolution T1-perfusion data with whole brain coverage is challenging due to possible loss in temporal resolution. This study takes the advantage of combining compressed-sensing with SENSE parallel-imaging i.e., Compressed-SENSE (CSENSE), to develop high-resolution whole brain T1-perfusion with improved temporality. The CSENSE enabled T1-perfusion derived rCBV values successfully differentiated high and low grade gliomas and matched with the histopathological grading. The rCBV cut-off value from CSENSE assisted T1-perfusion was similar to the routine T1-perfusion without-CSENSE of histopathology-matched gliomas.

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