Abstract #4858

High Resolution T1-Perfusion using Compressed-SENSE for Glioma Grading

Rakesh Kumar Gupta¹, Indrajit Saha², Anup Singh³, Pradeep Kumar Gupta¹, Rupsa Bhattacharjee ², Anandh K Ramaniharan ⁴, Rana Patir⁵, Sunita Ahlawat⁶, Jitender Saini⁷, and Marc Van Cauteren⁸

¹Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, ²Philips Health Systems, Philips India Limited, Gurgaon, India, ³Center for Biomedical Engineering, Indian Institute of Technology Delhi, Delhi, India, ⁴Philips Innovation Campus, Philips India Limited, Bangalore, India, ⁵Department of Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India, ⁶SRL Diagnostics, Fortis Memorial Research Institute, Gurgaon, India, ⁷Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, ⁸Philips HealthTech Asia Pacific, Tokyo, Japan

T1-perfusion MRI derived relative cerebral blood volume (rCBV) is a key bio-marker for pre-surgical grading of gliomas; however, acquiring clinically relevant higher resolution T1-perfusion data with whole brain coverage is challenging due to possible loss in temporal resolution. This study takes the advantage of combining compressed-sensing with SENSE parallel-imaging i.e., Compressed-SENSE (CSENSE), to develop high-resolution whole brain T1-perfusion with improved temporality. The CSENSE enabled T1-perfusion derived rCBV values successfully differentiated high and low grade gliomas and matched with the histopathological grading. The rCBV cut-off value from CSENSE assisted T1-perfusion was similar to the routine T1-perfusion without-CSENSE of histopathology-matched gliomas.

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