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Abstract #4860

Advanced MRI and MRS precursors to progression in Grade II and III Glioma

Tracy L Luks1, Yan Li1, Marisa LaFontaine1, Angela Jakary1, Michael Wahl2, Susan M Chang3, and Sarah J. Nelson1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, 3Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

The goal of this project is to identify serial advanced imaging markers that reveal tumor progression in grade II and III gliomas prior to the Response Assessment in Neuro-Oncology Criteria (RANO) criteria for progression. Serial advanced imaging demonstrated significant changes associated with tumor activity prior to the clinical determination of tumor progression. In diffusion imaging, there were declines in nFA, and an increase in nADC in the contrast enhancing lesions. In spectroscopic imaging, there were declines in nNAA and nCRE, and increases in nCho, nLIP and nLAC.

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