Diffusion tensor imaging (DTI) has been used in clinical research to identify microstructural changes in the heart following disease. However, the evidence supporting its use in the presence of abnormalities such as scar, hypertrophy and collagen infiltration is limited. Here, we investigate the application of DTI in fixed healthy, infarcted, hypertrophic and fibrotic mouse hearts, and validate these on a voxel-wise basis with high-resolution structure tensor synchrotron radiation imaging. Our findings show good agreement in helix angle estimation between the two imaging modalities across all hearts, and supports the clinical role of DTI in the presence of cardiac pathologies.
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