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Abstract #4881

Spin Echo Based Cardiac Diffusion Tensor Imaging of the Unfixed, Ex-vivo Porcine Heart at 7T and 3T

David Lohr1, Maxim Terekhov1, Andreas Max Weng2, Anja Schröder3, Heike Walles3, and Laura Maria Schreiber1

1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), University Hospital, Wuerzburg, Germany, 2Institute of Diagnostic and Interventional Radiology, University Hospital, Wuerzburg, Germany, 3Translational Center Regenerative Therapies (TLC-RT), Fraunhofer Institute for Silicate Research (ISC), Wuerzburg, Germany

7T, 3D, whole heart, high resolution, diffusion tensor data sets with 1.3mm isotropic voxels, unachievable in human in-vivo scans, were acquired for 8 ex-vivo pig hearts using a Stejskal-Tanner sequence with varying parallel imaging factors. ADC, FA, helix angle and secondary eigenvector angle values were analyzed and compared to a reference set of 26 ex-vivo hearts measured with the same protocol at 3T. Purpose of this study was quality assessment in DTI of the ex-vivo porcine heart at 7T. The proof of principle data acquired allows future optimization of acquisition approaches and helps translating the method to an in-vivo application.

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