Abstract #4891

A comparison of motion compensated spin echo (M2SE) and stimulated echo acquisition mode (STEAM) diffusion tensor cardiovascular magnetic resonance in the in vivo assessment of hypertrophic cardiomyopathy.

Zohya Khalique¹, Andrew Scott¹, Pedro Ferreira¹, Sonia Nielles-Vallespin², David Firmin¹, and Dudley Pennell¹

¹CMR Unit, Royal Brompton Hospital, London, United Kingdom, ²National Institutes of Health, Bethesda, MD, United States

Diffusion tensor cardiovascular magnetic resonance (DT-CMR) interrogates myocardial microstructure, using parameters such as mean diffusivity (MD), fractional anisotropy (FA) and secondary eigenvector angulation (E2A), an index of sheetlet orientation. We compared motion compensated spin echo (M2SE) and stimulated echo acquisition mode (STEAM) and their ability to distinguish hypertrophied fibrosed myocardium (LVH+Gd+) in hypertrophic cardiomyopathy.

M2SE discriminated areas of LVH+Gd+ best through FA and MD, whilst STEAM was more sensitive to changes in E2A mobility. FA derived from both M2SE and STEAM correlated significantly with extracellular volume.

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