Abstract #4909

MRI-based retrospective gating for PET reconstruction in rats: implementation and proof of principle study

Willy Gsell¹, Uwe Himmelreich¹, Arno Nauerth², Cesar Molinos³, Carlos Correcher³, Antonio J Gonzalez⁴, Sven Junge², Thorsten Greeb², Ramiro Polo³, Bryan Holvoet⁵, Christophe M Deroose⁵, and Michael Heidenreich²

¹Biomedical MRI, KU Leuven, Leuven, Belgium, ²Preclinical Imaging PCI, Bruker Biospin MRI, GmbH, Ettlingen, Germany, ³Preclinical Imaging NMI, Bruker Biospin MRI, GmbH, Valencia, Spain, ⁴Institute for Instrumentation in Molecular Imaging, i3M-CSIC, Valencia, Spain, ⁵Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium

We hereby report the implementation and the preliminary results of an MRI-based retrospective gating strategy for reconstructing simultaneously acquired PET data in rats (SPECMRI). Ejection fraction extracted from MRI, SPECMRI and ECG-gated PET were all within the same range (70.0 ± 3.5%, 72.5 ± 5.4% and 70.5 ±6% for MRI, ECG-gated and SPECMRI respectively). This new technique enables to ease the animal handling (no need for ECG electrodes) and provide true synchronization of PET and MRI data.

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