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Abstract #4924

High Resolution UTE-MRAs for Longitudinal Visualization of Revascularization and Blood-Brain Barrier Disruption on a Rat Transient Middle Cerebral Artery Occlusion Model

MungSoo Kang1 and HyungJoon Cho1

1Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea

Longitudinal study of revascularization and BBB disruption after ischemic stroke provides prognostic and therapeutic information. In this work, high resolution UTE-MRAs with superparamagnetic iron oxide nanoparticles (SPION) were performed on a rat tMCAO model to visualize revascularization and BBB disruption longitudinally. UTE-MRAs before and after SPION injection clearly visualized arterial vessels and all vessels, respectively. Thickened and twisted vessels at the rat brain surface of ipsilateral hemisphere were highly resolved (59 μm3 isotropic).

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