Abstract #4926

Increased vascular permeability in the lenticulostriate arteries results in increased hemosiderin deposition in the basal ganglia in aging and cognitive impairment

Axel Montagne¹, Giuseppe Barisano², Meng Law^1,2,3, Farshid Sepherband³, Arthur Toga³, and Berislav Zlokovic¹

¹Zilkha Neurogenetics Institute, University of Southern California, Los Angeles, CA, United States, ²Radiology, University of Southern California, Los Angeles, CA, United States, ³Stevens Institute of Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States

The intramural periarterial drainage pathway is critical for the elimination of metabolic waste products from the brain. In a number of neurological diseases such as Alzheimer’s Disease, blood-brain barrier damage and increased vascular permeability may play an important role in the pathogenesis. Leakiness of the blood-brain barrier allows fibrin(ogen), hemosiderin and metabolic wastes to exudate and deposit around the vessels in the basal ganglia. In order to test this hypothesis, we evaluated the relationship between blood-brain barrier permeability measured as ktrans and hemosiderin deposition in 76 subjects scanned at 3T MRI.

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