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Abstract #4972

Lactate, the new hope against brain damages in neonatal hypoxia-ischemia

Hélène Roumes1, Ursule Dumont1, Leslie Mazuel1, Stéphane Sanchez1, Jordy Blanc1, Véronique Bouchaud1, Jean-François Chateil1, and Anne-Karine Bouzier-Sore1

1Centre de Résonance Magnétique des Systèmes Biologiques - UMR 5536 - CNRS, BORDEAUX, France

Hypoxia-ischemia remains a major perinatal mortality and chronic disability cause in newborns. Hypothermia is the only clinically therapeutic approach but new therapy must be developed. Our aim was to study the neuroprotective role of lactate in rat neonatal hypoxic-ischemic model and to determine the best pattern to counteract brain damages. Interestingly, lactate was much more neuroprotective when administered after hypoxia (curative) than before (preventive). Single versus 48h injection of lactate were compared. Lactate shows significant and important neuroprotection (ADC, FA, immunohistochemistry, behavioral studies).

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