Meeting Banner
Abstract #4979

Fronto-striatal connectivity alterations in a prenatal ethanol exposure rat model: a resting-state functional MRI study

Shiyu Tang1, Su Xu1, Jaylyn Waddell2, Marie Hanscom2, Wenjun Zhu1, Rao Gullapalli1, and Sandra Mooney2

1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States

People with Fetal Alcohol Spectrum Disorders (FASDs) may present deficits in executive functions. The fronto-striatal circuit is a critical component of the fronto-basal ganglia pathway that plays an important role in executive processes. We used resting-state functional MRI to assess the effects of prenatal alcohol exposure on the functional interaction within the fronto-striatal circuit in a rat FASD model. Male alcohol-exposed rats, but not females, showed reduced fronto-striatal connectivity. Further exploratory analysis revealed a reduction in cortico-striatal connectivity in female alcohol-exposed rats, suggesting that prenatal alcohol exposure has sex dependent effects on executive and sensory processing functions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here