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Abstract #4981

Longitudinal evaluation of iron load with quantitative suceptibility mapping (QSM) in a primate model of Parkinson's disease

Mathieu David Santin1,2, Maxime Verdier1,2, Romain Valabregue1,2, Elodie Laffrat2, Lydia Yahia Cherif1,2, Alexandra Petiet1,2, Stéphane Lehéricy1,2, and Stéphane Hunot2

1CENIR, ICM, Paris, France, 2Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France

In this study, we performed a longitudinal follow-up of iron load in a primate model of Parkinson's disease using both QSM and R2* mapping. ROI definition was automatically performed using an in-house template computed from all acquired data. Statistical analyses revealed that QSM is more sensitive to model-induced variation in iron-rich regions compared to R2* mapping.

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