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Abstract #4987

Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in post-mortem frontal cortex of Alzheimer patients

Marjolein Bulk1,2, Walid M. Abdelmoula1, Wim Wiarda3, Itamar Ronen1, Jouke Dijkstra1, and Louise van der Weerd1

1Radiology, LUMC, Leiden, Netherlands, 2Percuros BV, Leiden, Netherlands, 3Netherlands Forensic Institute, The Hague, Netherlands

Previous imaging studies reported iron-induced T2* or phase contrast changes in the cortex of post-mortem brain tissue of patients with Alzheimer’s disease (AD), but comparison with a gold standard is lacking. This study used laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) as a gold standard for iron in post-mortem brain tissue of controls and AD patients and investigated the correlation between LA-ICP-MS, quantitative MRI (R2*, phase, and QSM) and histology. R2* and QSM showed the highest correlation with iron content; the correlation of phase with iron was weaker, probably due to its high orientation dependence.

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