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Abstract #4991

High resolution frequency difference mapping using ASPIRE phase combination

Korbinian Eckstein1, Siegfried Trattnig1, and Simon Daniel Robinson1

1High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

Frequency difference mapping (FDM) is a promising new method for investigating tissue microstructure. To date, images have been of quite low resolution and noise because of the need to use monopolar readout and two difference operations. We propose an improved approach – ASPIRE-FDM – which is based on a recently developed coil combination method which removes both phase offsets and phase gradients in readout direction in more efficient bipolar acquisitions. The resulting maps have drastically reduced noise and make feasible a four-fold reduction in voxel volume compared to prior work.

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