Glycosaminoglycan CEST (gagCEST) has been shown to be a useful tool for assessing changes in glycosaminoglycan concentrations in cartilage. However, accurate B0 referencing is necessary for observing reliable gagCEST. Here we investigate whether the quality of in vivo gagCEST images can be further improved by correction of both B0 and B1 inhomogeneity by using a novel water shift and B1 (WASABI) mapping method. We present results from 20 healthy volunteers acquired at 3T. A comparison with the outcome of WASSR B0 mapping shows that the application of the WASABI maps to inhomogeneity artefact correction is advantageous to gagCEST imaging.
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