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Abstract #5013

Comparison of B0 versus B0 and B1 field inhomogeneity correction for glycosaminoglycan chemical exchange saturation transfer imaging

Anja Müller-Lutz1, Alexandra Ljimani1, Julia Stabinska1, Hans-Jörg Wittsack1, and Christoph Schleich1

1Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, Dusseldorf, Germany

Glycosaminoglycan CEST (gagCEST) has been shown to be a useful tool for assessing changes in glycosaminoglycan concentrations in cartilage. However, accurate B0 referencing is necessary for observing reliable gagCEST. Here we investigate whether the quality of in vivo gagCEST images can be further improved by correction of both B0 and B1 inhomogeneity by using a novel water shift and B1 (WASABI) mapping method. We present results from 20 healthy volunteers acquired at 3T. A comparison with the outcome of WASSR B0 mapping shows that the application of the WASABI maps to inhomogeneity artefact correction is advantageous to gagCEST imaging.

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