Abstract #5029

Relaxivity of Ferumoxytol at 1.5T and 3.0T

Gesine Knobloch¹, Timothy Colgan¹, Curtis Wiens¹, Xiaoke Wang^1,2, Tilman Schubert¹, Diego Hernando³, and Scott Reeder^1,3,4,5,6

¹Department of Radiology, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ²Department of Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ³Department of Medical Physics, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁴Department of Biomedical Engineering, University of Wisconsin – School of Medicine and Public Health, Madison, WY, United States, ⁵Department of Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States, ⁶Department of Emergency Medicine, University of Wisconsin – School of Medicine and Public Health, Madison, WI, United States

Ferumoxytol (Feraheme, AMAG, Waltham, MA) is an iron supplement that has shown promise as an off-label alternative contrast agent for MRI. Optimization of imaging and dosing protocols requires accurate knowledge of the relaxation characteristics of ferumoxytol, which are currently not well understood. Therefore, the purpose of this work was to measure the r1, r2 and r2* relaxivity of ferumoxytol. Studies were performed at 1.5T and 3.0T over a range of concentrations, in saline, human plasma, and human blood, all at body temperature.

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