Abstract #5032

A compact solution for physiological parameters from ultrafast prostate DCE-MRI may reduce random and systematic errors

Xiaobing Fan¹, Dianning He², Aritrick Chatterjee¹, Shiyang Wang¹, Milica Medved¹, Federico D Pineda¹, Ambereen Yousuf¹, Tatjana Antic³, Aytekin Oto¹, and Gregory S Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Shenyang, China, ³Pathology, The University of Chicago, Chicago, IL, United States

The Tofts pharmacokinetic model requires multiple calculations for analysis of dynamic contrast enhanced (DCE) MRI. This can result in error propagation that reduces the accuracy of pharmacokinetic measurements. Here, we present a new compact solution for estimating physiological parameters based on changes in signal intensity, without the Tofts model. Human prostate DCE-MRI data were analyzed to compare physiological parameters estimated from proposed compact solution with the Tofts model. The K^trans and v_e from the compact solution correlated strongly with values from the Tofts Model. Bland–Altman plots showed moderate to excellent agreement between the compact solution and the Tofts Model.

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