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Abstract #5042

Simplified method for estimating chemical exchange rate in human knee cartilage from R1rho dispersion

Ping Wang1 and John C. Gore1

1Radiology and Radiological Sciences, Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Chemical exchange between water and exchangeable protons in macromolecules in knee cartilage can be quantified by fitting R dispersion data to a model. However, acquiring the entire dispersion curve is time consuming, which therefore hampers the application in clinical practice. We propose a simple three-point method for R dispersion data to estimate exchange rate. The method requires data acquired at three selected spin-locking frequencies instead of acquiring a full dispersion curve. The results show good agreement between the proposed method and measurements from the full dispersion data.

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