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Abstract #5054

Sodium Imaging of Untreated Cartilage Lesions in the Knee Joint: 3-months and 6-months Follow-up Study at 7T

Stefan Zbyn1,2,3, Markus Schreiner4, Vladimir Mlynarik1, Vladimir Juras1, Pavol Szomolanyi1, Didier Laurent5, Celeste Scotti5, Harry Haber5, Joerg Goldhahn5, Ewa Kubiak5, Xeni Deligianni6, Oliver Bieri6, Stefan Marlovits7, Miika T. Nieminen2,8,9, and Siegfried Trattnig1,3

1High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 4Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, 5Novartis Institutes for Biomedical Research, Basel, Switzerland, 6Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 7Department of Traumatology, Medical University of Vienna, Vienna, Austria, 8Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 9Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Sodium MRI was used for the follow-up of patients with cartilage lesions at 7T. MRI was obtained at baseline, 8-days, 3-months and 6-months follow-up. Regions-of-interest evaluations were performed in weight-bearing, non-weight-bearing and lesion area of femoral cartilage. Sodium values were significantly lower in lesion than in weight-bearing and non-weight-bearing regions at all follow-up measurements. On the other hand, weight-bearing and non-weight-bearing cartilage regions showed stable sodium values over the follow-up time. Sodium imaging allows noninvasive in vivo monitoring of changes in cartilage GAG content and thus can be useful for the evaluation of cartilage degeneration or cartilage regenerating therapies.

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