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Abstract #5067

Skeletal muscle tissue characterization of Duchenne muscular dystrophy patients by 1H- and 23Na-MRI

Teresa Gerhalter1,2, Lena V. Gast2, Benjamin Marty1, Regina Trollmann 3, Sophia Rügner 3, Stephanie Schüssler3, Frank Roemer2, Frederik B. Laun2, Michael Uder2, Pierre G. Carlier1, and Armin M. Nagel2

1NMR Laboratory, Institute of Myology, Paris, France, 2Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Department of Pediatrics, Division Neuropediatrics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disease leading to progressive muscle wasting. As there is a need to identify NMR variables as potential early sensitive indicators of dystrophic muscle response to treatment, we evaluated the sensitivity of 23Na NMR in DMD in comparison to the commonly used water T2 and fat fraction. Sodium anomalies seemed to be systematically present and precede water T2 increases and fatty degenerative changes, also in muscles that were relatively spared. Although still limited in the small number of subjects, the data supports that 23Na could be used to characterize early dystrophic muscle alteration.

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