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Abstract #5072

SVD Compression for Quantification of 31P Relaxation Time and Creatine Kinase Reaction Rate by 31P Magnetic Resonance Fingerprinting

Yuning Gu1, Mingrui Yang2, Charlie Y. Wang1, Debra F. McGivney2, Mark A. Griswold2, and Xin Yu1,2,3

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Radiology, Case Western Reserve University, Cleveland, OH, United States, 3Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

Magnetic resonance fingerprinting (MRF) provides the opportunity for efficient quantification of ATP synthesis using 31P magnetization transfer (MT) spectroscopy. However, the multi-compartment, multi-parametric nature of 31P MT experiments renders dictionary-matching computationally infeasible. In this study, singular value decomposition was employed for parameter estimation in a 31P MRF study that quantified creatine kinase activity. Such approach allowed dictionary compression by 16 fold and accelerated parameter matching by up to 80% without compromising matching accuracy. In vivo experiments on rat hindlimb (N=21) showed a 2.7-fold increase in measurement efficiency comparing to the conventional MT method using saturation transfer.

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